The lifting disease-free endurance since the s is chiefly attributed to the improved usage of bing chemotherapeutic agents and their better combination that is being established through multi-centered clinical surveies.
Find articles by Seema A. This article has been cited by other articles in PMC. Abstract Acute lymphoblastic leukemia ALL is the commonest childhood malignancy with high cure rates due to recent advances in central nervous system CNS prophylaxis.
The disease per se, as well as the prophylactic therapy, predisposes the child to complications such as cerebrovascular events, infections, drug toxicities, etc.
The purpose of this study is to highlight the pathophysiology and the imaging features with appropriate examples of these complications and to propose a diagnostic algorithm based on MRI.
Interpreting these scans in the light of clinical inputs very often helps the radiologist reach an appropriate diagnosis and help treatment and management. This therapy is administered using intrathecal methotrexate, high-dose chemotherapy, radiotherapy, or a combination of any of these.
However, patients with ALL can present with neurological complications as a result of this therapy and the underlying systemic effects of leukemia. The neurological complications in ALL can be divided into two broad categories: The latter have been divided into seven categories as shown in Table 1.
Our review focuses on the complications that have an acute presentation and can be promptly recognized on imaging. Table 1 Secondary manifestations of leukemia in brain Cerebrovascular Complications Pathophysiology Leukemia is often associated with leucocytosis, thrombocytopenia, sepsis, or coagulopathy.
These factors and certain therapeutic agents like glucocorticoids and L-asparginase used in the management of these tumors, predispose the patient to cerebrovascular events.
Imaging Hemorrhage is seen commonly and is often fatal. The mass effect associated with these lesions leads to complications.Acute Lymphocytic Leukemia (ALL) “Acute lymphocytic leukemia (ALL) is a type of cancer of the blood and bone marrow.” (Mayo, ) Also known as acute lymphoblastic leukemia and acute childhood leukemia.
Leukemia strikes both children and adults, and while survival rates are high, treatment is often difficult and always expensive. People who have been affected by Leukemia or Lymphoma, either directly or through a family member, understand the physical, emotional, .
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, accounting for about 75% of childhood leukemias and one-fourth of all pediatric cancers. The overall cure rates for children with ALL now approach 80%, prophylactic therapy of the central nervous system (CNS) being the cornerstone of this success.
Acute lymphoblastic leukaemia (ALL) is the most common malig- nancy in the paediatric age group. 1 Symptoms of ALL include anaemia, fever, bleeding tendency and fatigue.
2 Hypercalcaemia. Abstraction.
Summary. Acute lymphoblastic leukaemia (ALL) is the most common signifier of malignance in kids. Recently, many surveies have examined factors act uponing both the susceptibleness to ALL and the metamorphosis of widely used chemotherapeutic agents. Acute lymphoblastic leukemia (ALL).
ALL is the most common type of leukemia in children. But it can occur in adults. Acute myeloid leukemia (AML). AML is one of the most common types of acute leukemia in adults.
It can also occur in children. Chronic lymphocytic leukemia (CLL).